Download e-book for iPad: Chemical Synthesis of Nucleoside Analogues by Pedro Merino

By Pedro Merino

ISBN-10: 1118007514

ISBN-13: 9781118007518

Compiles present demonstrated and confirmed techniques to synthesize novel nucleoside analogues

Featuring contributions from major man made chemists from worldwide, this booklet brings jointly and describes validated and confirmed ways for the chemical synthesis of universal households of nucleoside analogues. Readers will learn how to create new nucleoside analogues with wanted healing houses through the use of numerous easy methods to chemically regulate ordinary nucleosides, including:

  • Changes to the heterocyclic base
  • Modification of substituents on the sugar ring
  • Replacement of the furanose ring by way of a unique carbo- or heterocyclic ring
  • Introduction of conformational restrictions
  • Synthesis of enantiomers
  • Preparation of hydrolitically sturdy C-nucleosides

Chemical Synthesis of Nucleoside Analogues covers the entire significant periods of nucleosides, together with pronucleotides, C-nucleosides, carbanucleosides, and PNA monomers that have proven nice promise as beginning issues for the synthesis of nucleoside analogues. The publication additionally comprises experimental tactics for key reactions with regards to the synthesis of nucleoside analogues, delivering a important software for the practise of a couple of assorted compounds.

Throughout the ebook, chemical schemes and figures aid readers greater comprehend the chemical buildings of nucleoside analogues and the equipment used to synthesize them. wide references function a gateway to the starting to be physique of unique learn reviews and reports within the field.

Synthetically transformed nucleosides have confirmed their worth as healing medicinal drugs, particularly as antiviral and antitumor brokers. even though, a lot of those nucleoside analogues have bad uncomfortable side effects. With Chemical Synthesis of Nucleoside Analogues as their advisor, researchers have a brand new instrument for synthesizing a brand new iteration of nucleoside analogues that may be used as healing medicinal drugs with fewer undesirable facet effects.

Show description

Read or Download Chemical Synthesis of Nucleoside Analogues PDF

Best biochemistry books

New PDF release: Glutamine in Clinical Nutrition (Nutrition and Health)

Glutamine is the main considerable amino acid and is a massive contributor to complete physique nitrogen metabolism and is taken into account to be “conditionally crucial. ” Glutamine in health and wellbeing and ailment offers the applying of present dietary wisdom through physicians and dietitians and comprises rising fields of technology and critical discoveries.

Download e-book for iPad: Fat Chemistry: The Science behind Obesity by Claire S Allardyce

At present, the wellbeing and fitness of over part the grownup inhabitants within the united kingdom suffers due to fats. the united kingdom isn't on my own: weight problems is an international challenge, however the populations of a few international locations are heavier than others. This e-book probes the chemistry of fats in bodies, offering a special perception into knowing weight problems, and the way this fabric turns into accrued to reason weight problems with specific emphasis at the contribution of food past energy.

Regulatory Proteolytic Enzymes and Their Inhibitors: 11th by S. Magnusson,etc.,Staffan Magnusson,Martin Ottesen,Bent PDF

Regulatory Proteolytic Enzymes and Their Inhibitors contains contributed papers from the eleventh assembly of the Federation of ecu Biochemical Societies in Copenhagen in 1977. This assortment describes the position of proteases within the physiological rules, an issue of the activation and de-activation of enzymes.

Get Alzheimer’s Disease II (Topics in Medicinal Chemistry) PDF

Medicinal chemistry is either technology and artwork. The technological know-how of medicinal chemistry bargains mankind considered one of its most sensible hopes for making improvements to the standard of existence. The paintings of medicinal chemistry keeps to problem its practitioners with the necessity for either instinct and adventure to find new medicinal drugs. for this reason sharing the adventure of drug learn is uniquely important to the sphere of medicinal chemistry.

Additional resources for Chemical Synthesis of Nucleoside Analogues

Example text

Download PDF sample

Chemical Synthesis of Nucleoside Analogues by Pedro Merino

by David

Rated 4.61 of 5 – based on 43 votes