Download e-book for iPad: Chemical Synthesis of Nucleoside Analogues by Pedro Merino

By Pedro Merino

ISBN-10: 1118007514

ISBN-13: 9781118007518

Compiles present demonstrated and confirmed techniques to synthesize novel nucleoside analogues

Featuring contributions from major man made chemists from worldwide, this booklet brings jointly and describes validated and confirmed ways for the chemical synthesis of universal households of nucleoside analogues. Readers will learn how to create new nucleoside analogues with wanted healing houses through the use of numerous easy methods to chemically regulate ordinary nucleosides, including:

  • Changes to the heterocyclic base
  • Modification of substituents on the sugar ring
  • Replacement of the furanose ring by way of a unique carbo- or heterocyclic ring
  • Introduction of conformational restrictions
  • Synthesis of enantiomers
  • Preparation of hydrolitically sturdy C-nucleosides

Chemical Synthesis of Nucleoside Analogues covers the entire significant periods of nucleosides, together with pronucleotides, C-nucleosides, carbanucleosides, and PNA monomers that have proven nice promise as beginning issues for the synthesis of nucleoside analogues. The publication additionally comprises experimental tactics for key reactions with regards to the synthesis of nucleoside analogues, delivering a important software for the practise of a couple of assorted compounds.

Throughout the ebook, chemical schemes and figures aid readers greater comprehend the chemical buildings of nucleoside analogues and the equipment used to synthesize them. wide references function a gateway to the starting to be physique of unique learn reviews and reports within the field.

Synthetically transformed nucleosides have confirmed their worth as healing medicinal drugs, particularly as antiviral and antitumor brokers. even though, a lot of those nucleoside analogues have bad uncomfortable side effects. With Chemical Synthesis of Nucleoside Analogues as their advisor, researchers have a brand new instrument for synthesizing a brand new iteration of nucleoside analogues that may be used as healing medicinal drugs with fewer undesirable facet effects.

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Chemical Synthesis of Nucleoside Analogues by Pedro Merino


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